GameMaker Studio 2's support for Spine is dependent on the version of the Spine Runtimes that YoYo Games, the developers of GameMaker, have integrated. As of the information provided, GameMaker Studio 2 was last reported to support Spine Runtimes 3.8. This means that to ensure compatibility, your Spine projects should be exported using Spine Editor version 3.8 or earlier. There has been discussion and anticipation around updating GameMaker's Spine Runtimes to support newer versions of Spine, including mentions of plans to update to Spine 4.0. However, there is no confirmed support for Spine 4.2 in GameMaker Studio 2 as of the latest information available. It's important to match the Spine Editor version with the supported runtime version in GameMaker Studio 2 to avoid issues with animation and rendering.