Sorry you are having trouble. You can reset your Spine settings by deleting:
~/Library/Application Support/Spine/prefs.json
Hopefully that allows Spine to run again for you. Also, you can reset recent files by deleting recent.json and your view layout by deleting views.json. You may want to backup those files first.
The filtering settings shouldn't cause such a problem. Enabling multisample anti-aliasing (MSAA) might, since that is done when Spine is started. It's supposed to fallback to no MSAA if it isn't available, but we're at the mercy of the graphics card/driver.
Another potential problem is that some OS X software seems to interfere with Spine. We've not been able to figure out exactly what is going on, despite working with some of the authors of the conflicting software. Antivirus, Finder "enhancements", or other similar software may cause Spine to hang on start up. For example, Default Folder X causes Spine to hang and Rescue Time needs to be closed when Spine is started. Display Link, Duet Display, Twomon, and other display link programs may crash Spine when maximized.
We recently released 3.6.52. To see if that is causing your problem, you can create a text file here:
~/Library/Application Support/Spine/version.txt
Inside the text file, put the version of Spine you want to load, eg 3.6.51. The next time you start Spine, it will use that version.
